Hunting Genetic and Cancer Modification
The current view in medical research states that the cause of most cancers is genetic mutations. For example, according to the National Human Genome Research Institute (NHGRI), the NIH Institute, "all cancers are based on genetic mutations in immune cells." Genetic engineering is big business. Just look at the NIH budget allocated for genetic mutation, the number of biotech companies chasing genetic mutations, the size of licensing agreements between biotech and pharmaceutical companies that aim to use newly discovered genetic mutations, and the amount of media coverage for genetic mutations and so-called "connecting" with diseases. However, this colossal effort and billions of dollars have yielded little in return and few benefits to society. The reason for this limited success is simple. The cause of cancer is not a genetic mutation.
The BRCA1 gene story is a typical example of genetic predisposition.
The mystery of BRCA1
Genetics, in turn, produce proteins, which are the building blocks of cells. Protein intake is strictly controlled. The mutated gene has an unusual concentration of its proteins, which can lead to disease. In 1994, Mark Skolnick, Ph.D., discovered the BRCA1 gene (BRCA1 shorter than BReast CAncer 1). After the diagnosis, scientists observed a shallow level of BRCA1 protein in breast cancer tissues. The BRCA1 protein suppresses the cell cycle, meaning that the protein inhibits cell duplication. This look has caused a great deal of excitement. At the time, scientists believed that they were in the process of finding the cause of breast cancer. They assume that patients with breast cancer should have a modified BRCA1 type, which will explain the decrease in protein production and the excessive replication of breast cancer cells in the tumors.
In the United States, 180,000 cases of breast cancer are diagnosed each year. However, the BRCA1 type is modified in less than 5 percent of these cases. More than 95% of patients with breast cancer have a genetic mutation.
So here's the mystery. If the gene is not altered in most patients with breast cancer, why do tissues show low levels of BRCA1 protein? Today, this is one of the biggest mysteries in cancer research.
BRCA1 type is no different. Many common (unmodified) types show abnormal (increased or decreased) production of abnormal cancer proteins. In addition, research also reports strange gene expression in other diseases, such as atherosclerosis, obesity, osteoarthritis, type II diabetes, alopecia, type I diabetes, multiple sclerosis, asthma, lupus, thyroiditis, inflammatory bowel disease, rheumatoid arthritis, psoriasis, atopic dermatitis, and rheumatoid artery disease.
Discovery
A virus is a collection of genes. Repetitively, some viruses reside in the host cell and use cell machinery to replicate. What is the effect of a gene on cell protein production?
Think of genetics as a protein assembly line. Like all assembly lines, the gene consists of two parts, the conveyor (genetic code) and the control panel (gene promoter/enhancer). Consider a mobile phone store that includes a product called BRCA1. One of the many buttons on the control panel is called the N-box. Pressing a button increases productivity. However, only a few operators (called transcript factors), those who pass a special certificate (called a p300 test), have permission to press this button. What happens when a virus opens a store across the street from a cell phone store (called a latent infection) to produce its viral products?
The control panel in the virus store also has an N-box button. To start production, the virus begins hiring other certified operators. What is the effect of this "hiring" on the number of BRCA1 units available? The number is declining. In addition, degeneration is evident even before the virus begins to be produced ("hiring" is what causes the effect, not the viral proteins). The virus assembly line competes with the BRCA1 assembly line of certified operators, and hiring them prevents the mobile store from producing large or "healthy" BRCA1 units. A lower number of BRCA1 units leads to excessive cell proliferation and breast cancer. (See technical description in a recent paper published in the European Journal of Cancer.)
Infectious viruses cause abnormal production of specific genes, and as a result, other chronic diseases develop. This sequence of events easily explains why people suffering from obesity are also more likely to suffer from diabetes, cancer, and heart disease and why recent studies indicate that a low-fat diet does not protect against breast cancer. It also explains the extraordinary phenomenon that male pattern baldness is associated with heart disease and prostate cancer. In general, this sequence of events quickly identifies many symptoms that indicate the presence or co-occurrence of chronic diseases.
Drs first described this discovery. In his book Microcompetition with Foreign DNA and the Origin of Chronic Disease, Hanan Polansky published by the Center for the Biology of Chronic Disease.
In summary: the cause of cancer, and other incurable diseases, is not a genetic mutation, a viral infection.
Social Scientific Response
What does the scientific community say about the discovery of Dr. Polansky?
Consider what the famous heart surgeon and "Living Legend," Michael E. DeBakey, says about the discovery, "The basic idea of the basic concept of chronic disease presented by Drs. Polansky is very interesting, exciting… Perhaps the series can be held to provide a forum for further discussion and scrutiny.
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