Since the beginning of the pandemic, the mercurial nature of the coronavirus has been on display. Some people get mild, cold-like illnesses or even have no symptoms when infected, while other people become severely ill and may die from COVID-19.
What determines that fate is complicated and somewhat mysterious. Researchers are looking at a wide variety of factors that may play a role — everything from demographics to preexisting conditions to vaccination status and even genetic clues.
Researchers know that older people are more likely to have severe complications of the disease. The unvaccinated, too, have an increased risk of hospitalization and death compared with people who have gotten their COVID shots.
Unvaccinated people age 50 and older were 12 times as likely to die from COVID-19 as vaccinated people who had gotten two or more booster shots, August data from the U.S. Centers for Disease Control and Prevention indicate. For instance, among the unvaccinated there were 5.46 deaths per 100,000 people on August 28, compared with 0.49 per 100,000 for those with two-plus boosters.
Even among the vaxxed the number of shots counts. That same month, people 50 and older who got their first two shots and only one booster were nearly three times as likely to die (1.27 deaths per 100,000) as their peers who got two or more boosters.
Preexisting health problems
A litany of health conditions, including heart disease, kidney disease, chronic obstructive pulmonary disease (COPD), diabetes and obesity, increase the risk of bad outcomes from COVID-19 at any age. Yet some types of asthma may protect against the disease (SN: 5/2/22).
Cancer patients are among the most vulnerable to COVID-19. But even among cancer patients, some people are more vulnerable than others.
Cancer patients who are immunosuppressed, either because of problems with their immune systems or because they are taking immune-dampening drugs, are more likely to get severe COVID-19, die or develop cytokine storm — a whirlwind of immune chemicals that can set off tissue- and organ-damaging inflammation, researchers report November 3 in JAMA Oncology. The effect was worse for immunosuppressed people who were getting immunotherapy for cancer, compared with people getting other chemotherapies or no treatment.
That means cancer patients with weakened immune systems “should be very careful and adopt strict measures to prevent them from catching COVID-19,” says study coauthor Chris Labaki, a cancer researcher at Dana-Farber Cancer Institute in Boston.
“Wear masks as much as possible, clean everything, including washing your hands. Maybe don’t go to crowded public places where the chance of catching COVID-19 might be higher.” People who have cancer patients in their lives may also want to take more care to avoid the coronavirus, he says
Genetic clues
But young and otherwise healthy people may get really sick, be hospitalized or even die from COVID-19 too. It’s hard to predict who might succumb, but researchers are searching for genetic clues.
Some studies have found that versions of genes inherited from Neandertals may protect against COVID-19, while other genetic heirlooms passed down from Neandertals can up the risk of severe disease (SN: 2/17/21; SN: 10/2/20).
A massive international study examining DNA from more than 28,000 COVID-19 patients and almost 600,000 people who hadn’t been infected (to the best of their knowledge) confirmed that inheritance from Neandertals is involved in COVID-19 susceptibility.
The study also confirmed a previous finding that people with type O blood may have some protection against getting infected with the coronavirus (SN: 7/8/21). Exactly what accounts for the protection is still not known.
People with rare variants in a gene called toll-like receptor 7, or TLR7, are 5.3 times more likely to get severe COVID-19 than those who don’t have the variants, the team also reported November 3 in PLOS Genetics. Biologically, the link makes sense. TLR7’s protein is involved in signaling the immune system that a virus has invaded. Part of its duties include marshaling interferons, immune system chemicals that are some of the first responders to viral infections (SN: 8/6/20). Interferons warn cells to raise their antiviral defenses and help to kill infected cells.
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