WHEN LIVING WITH DEPRESSION

The current standard of care for treatment of depression based on what we call the monoamine deficiency hypothesis.    Essentially presuming that one of neurotransmitters in brain deficient or underactive.                                Neurotransmitters can be thought of as the chemical Messengers within the brain.              It was helps one cell in the brain communicate along with another to pass that message along .but the reality is there are more than a hundred neurotransmitters in the brain. We thought the primary pathology  the primary cause of depression was Some abnormalities in the neurotransmitters, specially serotonin or norepinephrine. However, norepinephrine and serotonin did not seem to be able to account for the symptoms of depression who had major depression. Instead, the chemical Messengers between the nerve cells in the higher centers of the brain involved in regulating mood and emotion, which include glutamate and GA BA, were possibilities as alternative causes for the symptoms of depression. We know that these two, which, are the most ubiquitous and abundant neurotransmitters in the brain. Actually regulating how the brain is changing over time and adapting. When you are exposed to severe and chronic stress like people experience as they have  depression,  you lose some of these connections between the nerve cells and communicate in these circuits becomes  inefficient and noisy. Because of noisy communication in these circuits involved in regulating mood and emotion, We think that the loose of this synaptic connections contribute to the biology of the depression. It's critical to understand the neurology of depression and how the brain plays an important role in that for two main reasons. Once it helps us understand how the disease develop and progresses, and we can start to target treatments based on that. There are clear difference between a healthy and a depressed brain. And the exciting thing is when you treat that depression effectively, the brain goes back to looking like a healthy brain. We recognize that the treatment for depression is a long term process. Because for many people, depression is a long term disorder. So we need new treatments. We've needed new ways to approach depression for people that haven't responded well to their prior treatments. We are in a new era of psychiatry. This is a paradigm shift away from a model of dopaminergic deficiency to a fuller understanding of the brain as a complex neurochemical organ.                          Depression : Note to sad self...don't let depression get to you, don't let it win by continuing the same depressed cycle of thinking. Depression is not always a sad face or suicide notes. Sometimes fake laughter, smiles and jokes. Depression is not always easy to notice. Take the time to notice if I was talking about something depressing other people will get depressed listening to it and no one likes around to hear depressing news, if you want happiness to come then speak happiness and snap yourself out of them suicidal thoughts before they get to you, do a gratitude list every day. People talking about depressing stories push them happy people away and only attract depressing people or no people at all,  so they live a depressing life. Don't wait for happiness to come, speak happiness now and come your way, but only after enough repetition of positive thinking and speaking for people to eventually notice it months down the track.