The question of how to live a long, healthy life is increasingly at the forefront of medical research. While centuries ago some may have turned to finding mythical immortality-granting items like the Holy Grail, scientists now say that achieving longevity may rely on eating the right foods, adopting healthy habits, and remaining socially active.
Reaching your hundredth birthday means you become a member of a “special club” of centenariansTrusted Source. While researchers believe the number of centenarians was very low before 1900, today many more people are able to reach this ripe old age.
As of 2021, there were an estimated 573,000 centenarians globally. The United Nations expects that number to jump rapidly, with a reported estimate of 3.7 million by 2050.
What do centenarians do to help them reach triple-digit birthdays — what is their secret? Medical News Today spoke with six experts to find out what the “secret sauce” behind longevity is.
Blue Zones: What are they?
In 2016, National Geographic Fellow Dan Buettner and his team published a studyTrusted Source on what they found to be the secrets to longevity.
Dubbed the Blue Zones, Buettner identified five specific areas of the world where people consistently live over 100 years of age. These areas are:
“These are places where human beings have lived manifestly longest,” Buettner explained to Medical News Today. “They’ve achieved the health outcomes we want: long lives largely free of chronic diseaseTrusted Source. Since only 80% of how long we live is dictated by disease, these people’s lifestyles and environments offer us instructions and clues for how we can set up our lives to live longer.”
Within these five areas, Buettner discovered there were nine common practices that people followed that might explain their slower aging process. Called the Power 9, they include:
- move naturally
- have a purposeTrusted Source in life
- reduce stress
- practice the 80% diet rule, which is to stop eating when 80% full
- favor a plant-based diet
- drink alcohol in moderate amounts
- belong to a communityTrusted Source
- put family first
- keep a social circle that supports healthy behaviors.
Loneliness, said Buettner, is a top risk factor for a shorter life, so preventing that as much as we can could help add years to our lives:
“We know that lonely people are expected to live 8 fewer years than well-connected people and that health behaviors [are] measurably contagious. People in Blue Zones are in socially connected villages with strong social ties, which gives them a longevity edge from the very beginning.”
“There’s no short-term fix [or] supplement for longevity,” he added. “Learn plant-based dishes that you like and cook at home. Curate a social circle of three to five healthy friends [who] will care about you on a bad day. Health behaviors are contagious, and friends tend to be long-term adventures.”
As diet makes up a few of the Power 9 learned from Blue Zones, Buettner has also launched the Blue Zone Food Guidelines that feature 11 recommendations reflecting how the world’s longest-living people ate for most of their lives.
“If you want to know what a centenarian [did to live] to be 100, you have to know what they ate during their whole [life],” he said. “Working with Harvard for my book The Blue Zones Kitchen, we collected 155 dietary studies done in all Blue Zones over the past 80 years and averaged them.”
“It was clear that over 90% of their traditional dietary intake came from whole food, plant-based sources [and] was about 65% complex carbs,” noted Buettner. “The pillars of every longevity diet in the world are whole grains, nuts, greens, and other garden vegetables, tubersTrusted Source, and beans.”
Dr. Valter Longo, Edna M. Jones Chair in Gerontology and professor of gerontology and biological sciences at the USC Leonard Davis School of Gerontology, developed the Longevity DietTrusted Source after years of research into aging, nutrition, and disease.
“The Longevity Diet, based on [the] five pillars of longevity, entails all of the everyday and periodic dietary habits that are associated with increased longevity and healthspan,” he explained to MNT.
The main facets of the Longevity Diet include:
- eating a low-protein pescatarian diet until the age of 65–70 years, followed by moderate proteins later in life
- fasting for 12 hours every night
- doing, on average, three cycles of a fasting-mimicking diet per year, each lasting 5 days.
“Because diet [is] intended as ‘how and what we eat’ and not as a method to lose weight, [it] can regulate the genes that regulate the aging process, but also those that regulate the removal of damaged components of cells and the regeneration of parts of various tissues and organs,” Dr. Longo added.
Additionally, previous research suggests that the Mediterranean diet can also provide benefits when it comes to longevity.
A review published in January 2020 concluded that the Mediterranean diet helps slow downTrusted Source the progression of aging and the onset of frailtyTrusted Source in older age.
And
Does the Mediterranean diet hold the key to longevity?
Can you eat your way to a longer, healthier life? And if so, what diet might best foster longevity? Over the past decade or so, a long string of studies has added to the evidence that a Mediterranean-type diet may do wonders for the body and mind. In this podcast episode, we look at what this type of diet can and cannot do for our health and lifespan.
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How does the Mediterranean diet promote longevity? We investigate, In Conversation. Illustration by Andrew Nguyen for Medical News Today.
Who, by now, has not heard of the many benefits of the Mediterranean diet? Characterized by a reliance on fresh, whole vegetables, fruits, and legumes, with a moderate amount of oily fish, this diet seems to help with everything from weight loss to better heart health.
In 2025 alone, different studies have found that a Mediterranean-type diet is linked to better brain health, a lower risk of cancer, lower blood pressure, and even a decreased risk of chronic constipation.
Research looking at how a Mediterranean diet may help protect memory, for instance, has suggested that it has a unique and beneficial effect on the gut, which could influence what happens in other parts of the body.
In time, some researchers have even come up with certain modified versions of the generic Mediterranean diet, in order to help with specific health issues, many of which appear as the body ages.
Most recently, a team from Spain found that following a lower-calorie Mediterranean diet was associated with improved weight management and bone density. The best-known modified versions of this diet, however, are the Green Mediterranean diet and the MIND diet.
The Green Mediterranean diet emphasizes whole, fresh, plant-based foods and does not include any meat. This version is meant to be not only more environmentally friendly but also better at reducing visceral fat — the type of fat that accumulates around organs, and can cause them damage.
It may also help slow down brain aging and lower blood sugar levels, recent research has shown. The MIND diet, however — which combines elements of the classic Mediterranean and the Dietary Approaches to Stop Hypertension (DASH) diets — was specifically designed to fight cognitive decline.
In this episode of In Conversation, Thomas (Tom) Barber, MD, helps us unpick the evidence linking a Mediterranean diet to a longer, healthier life, and offers his own tips on how to make our diets healthier as we continue our journeys through life.
Dr. Barber is a professor of endocrinology, consultant endocrinologist, and obesity expert at the University Hospitals Coventry and Warwickshire, the University of Warwick, and Coventry University in the United Kingdom. In 2023, he and his colleagues published a review of the existing evidence discussing the effects of the Mediterranean diet on health and the gut microbiota.
Dr. Barber has previously joined us on In Conversation to lend his expert perspective on the history of insulin therapy, lifestyle changes to reverse prediabetes, and what a person can do to slow down diabetes-related brain aging.
You can listen to our current podcast episode in full below or on your preferred streaming platform.
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In Conversation: What makes a diet truly heart-healthy?
Two nutrition studies recently made the headlines when they sounded alarm bells regarding the impact of dietary choices on heart health. What are the “ingredients” of a truly heart-healthy diet, and which foods should we avoid and why if we want to lower our risk of cardiovascular disease? This podcast episode finds answers to these and other questions related to heart-healthy dietary choices.
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What are the core ingredients of a heart-healthy diet? Our In Conversation podcast gets to the heart of the matter. Illustration by Andrew Nguyen for Medical News Today.
In April 2024, two nutrition studies made the headlines, emphasizing the critical impact of diet on cardiovascular health.
The first study, which appeared in The American Journal of Clinical Nutrition on April 8, was conducted by researchers from the Singapore Institute of Food and Biotechnology Innovation and the Agency for Science, Technology and Research in Singapore.
It involved 89 adults who were at risk for type 2 diabetes, and it made a finding that might, at first, sound surprising, namely: That eating plant-based meat substitutes offered no significant benefits to heart health over actual animal meat.
The second study — whose results were presented at the American College of Cardiology’s Annual Scientific Session at the beginning of April 2024 — was led by experts from Piedmont Athens Regional Hospital in Athens, GA.
It analyzed data from 3,170 participants in the National Health and Nutrition Examination Survey (NHANES)Trusted Source in the United States, all of whom were adults with cardiovascular disease.
This study found that 89% of these consumed more than double the “ideal” allowance recommended by the American Heart Association, which is 1,500 milligrams (mg)Trusted Source of sodium (salt) per day.
But why are certain foods, regardless of whether or not they are plant-based, so bad for the heart? How does salt impact the cardiovascular system? And what makes a diet truly heart-healthy?
In this episode of In Conversation, we discuss these questions and heart-healthy diet tips in conversation with our special guest, Prof. Oyinlola Oyebode, PhD, professor of public health at Queen Mary, University of London, in the United Kingdom.
Oyebode specializes in behavioral risk factors for noncommunicable diseases, particularly diet and issues affecting the health of marginalized populations.
Listen to our podcast episode in full below or on your preferred streaming platform.
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What to know about the Blue Zone diet and other healthy habits for longevity
The question of how to live a long, healthy life is increasingly at the forefront of medical research. While centuries ago some may have turned to finding mythical immortality-granting items like the Holy Grail, scientists now say that achieving longevity may rely on eating the right foods, adopting healthy habits, and remaining socially active.
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Our experts share tips on how to live a long and healthy life. Image credit: imamember/Getty Images.
Reaching your hundredth birthday means you become a member of a “special club” of centenariansTrusted Source. While researchers believe the number of centenarians was very low before 1900, today many more people are able to reach this ripe old age.
As of 2021, there were an estimated 573,000 centenarians globally. The United Nations expects that number to jump rapidly, with a reported estimate of 3.7 million by 2050.
What do centenarians do to help them reach triple-digit birthdays — what is their secret? Medical News Today spoke with six experts to find out what the “secret sauce” behind longevity is.
In 2016, National Geographic Fellow Dan Buettner and his team published a studyTrusted Source on what they found to be the secrets to longevity.
Dubbed the Blue Zones, Buettner identified five specific areas of the world where people consistently live over 100 years of age. These areas are:
“These are places where human beings have lived manifestly longest,” Buettner explained to Medical News Today. “They’ve achieved the health outcomes we want: long lives largely free of chronic diseaseTrusted Source. Since only 80% of how long we live is dictated by disease, these people’s lifestyles and environments offer us instructions and clues for how we can set up our lives to live longer.”
Within these five areas, Buettner discovered there were nine common practices that people followed that might explain their slower aging process. Called the Power 9, they include:
- move naturally
- have a purposeTrusted Source in life
- reduce stress
- practice the 80% diet rule, which is to stop eating when 80% full
- favor a plant-based diet
- drink alcohol in moderate amounts
- belong to a communityTrusted Source
- put family first
- keep a social circle that supports healthy behaviors.
Loneliness, said Buettner, is a top risk factor for a shorter life, so preventing that as much as we can could help add years to our lives:
“We know that lonely people are expected to live 8 fewer years than well-connected people and that health behaviors [are] measurably contagious. People in Blue Zones are in socially connected villages with strong social ties, which gives them a longevity edge from the very beginning.”
“There’s no short-term fix [or] supplement for longevity,” he added. “Learn plant-based dishes that you like and cook at home. Curate a social circle of three to five healthy friends [who] will care about you on a bad day. Health behaviors are contagious, and friends tend to be long-term adventures.”
As diet makes up a few of the Power 9 learned from Blue Zones, Buettner has also launched the Blue Zone Food Guidelines that feature 11 recommendations reflecting how the world’s longest-living people ate for most of their lives.
“If you want to know what a centenarian [did to live] to be 100, you have to know what they ate during their whole [life],” he said. “Working with Harvard for my book The Blue Zones Kitchen, we collected 155 dietary studies done in all Blue Zones over the past 80 years and averaged them.”
“It was clear that over 90% of their traditional dietary intake came from whole food, plant-based sources [and] was about 65% complex carbs,” noted Buettner. “The pillars of every longevity diet in the world are whole grains, nuts, greens, and other garden vegetables, tubersTrusted Source, and beans.”
Dr. Valter Longo, Edna M. Jones Chair in Gerontology and professor of gerontology and biological sciences at the USC Leonard Davis School of Gerontology, developed the Longevity DietTrusted Source after years of research into aging, nutrition, and disease.
“The Longevity Diet, based on [the] five pillars of longevity, entails all of the everyday and periodic dietary habits that are associated with increased longevity and healthspan,” he explained to MNT.
The main facets of the Longevity Diet include:
- eating a low-protein pescatarian diet until the age of 65–70 years, followed by moderate proteins later in life
- fasting for 12 hours every night
- doing, on average, three cycles of a fasting-mimicking diet per year, each lasting 5 days.
“Because diet [is] intended as ‘how and what we eat’ and not as a method to lose weight, [it] can regulate the genes that regulate the aging process, but also those that regulate the removal of damaged components of cells and the regeneration of parts of various tissues and organs,” Dr. Longo added.
Additionally, previous research suggests that the Mediterranean diet can also provide benefits when it comes to longevity.
A review published in January 2020 concluded that the Mediterranean diet helps slow downTrusted Source the progression of aging and the onset of frailtyTrusted Source in older age.
And research published in March 2021 says adhering to the Mediterranean diet may add yearsTrusted Source to a person’s life.
Why is diet so important for longevity?
According to Monique Richard, a registered dietitian nutritionist, owner of Nutrition-In-Sight in Johnson City, TN, and national media spokesperson for the Academy of Nutrition and Dietetics, when it comes to eating for longevity, diets like the Blue Zone Diet, Longevity Diet, and Mediterranean diet stand out because of the lifestyle components they share.
“Examples of commonalities observed within these populations include more families and individuals growingTrusted Source and consuming their food [and] eating more whole foods, as in closest to what Mother Nature has made versus derived from a manufacturing plant, industrial farm, or fast food chain,” she explained to MNT.
“Overall intake and composition of these diets include less highly-processed foods, therefore often automatically decreasing levels of sodium, artificial flavors, colorings, and preservatives, fats or added sugar.” Richard noted.
“These dietary patterns often include foods lower in saturated fats, cholesterol, and calories, including more foods that are richer in nutrients such as fiber, antioxidants like vitamin C, E, A, [and] B, and higher in minerals such as potassium, magnesium, and iodine.”
– Monique Richard
When looking to make diet changes to increase longevity, Richard said it is not just about extending life, but also about increasing its quality.
She suggested:
- take inventory of what food you have on hand and what should be added or subtracted
- reassess your sugary beverageTrusted Source intake
- examine how much animal-derived meats and other foods you are eating and consider alternatives
- cook more at home
- take the time to shop for groceries rather than using a delivery system
- plant herbs in pots or cartons on a window sill or small deck if you do not have a garden space to cultivate them
- shop at the farmer’s market
- experiment with “new to you” foods
- brighten up dishes with herbs and spices
- add more greens, beans, lentils, and vegetables into your daily diet
- take time to celebrate food.
“The emphasis is not on restriction or negative consequences, but leaning into true quality, consistency, and overall health with a pillar of foundational pure, wholesome factors,” Richard said.
“Don’t forget to slow down with eating, with chewing, with making or creating a meal, with making time to stop and smell the flowers, [and] with making long-lasting meaningful changes,” she added.
The “power of positive thinking” is known to be beneficial to a person’s overall mental health. However, previous research shows that a positive attitude may even help a person live longer.
A study published in August 2019 found that being optimistic was associated with a person living 11-15% longer and having a stronger likelihood of living to age 85 or older.
Research published in October 2022 suggested that positive-thinking women in an ethnically diverse United States population lived an average of 4.4 years moreTrusted Source than those who did not think positively.
“Having a positive, optimistic outlook reduces our risk for developing chronic diseases and gives us a greater chance of living past 85,” Dr. Karen D. Sullivan, a board-certified neuropsychologist and owner of I CARE FOR YOUR BRAIN in Pinehurst, NC explained to MNT.
“The mechanism behind these benefits is thought to be related to the protection optimism offers against the inflammatory damage of stress. Studies on negative emotions show a weakening effectTrusted Source on the immune system.”
– Dr. Karen D. Sullivan
Additionally, Dr. Karen Miller, a neuropsychologist, geropsychologist, and senior director of the Brain Wellness and Lifestyle Programs at Pacific Neuroscience Institute in Santa Monica, CA, noted that inflammation caused by stress is one of the culprits leading to more rapid aging, more physical difficulties, and more cognitive difficultiesTrusted Source.
“So when we’re thinking positive and engaging in positive behaviors, such as […] meditation, yoga, participating in our own personal religious practicesTrusted Source, getting out and walking, exercising, [or] enjoying the fresh airTrusted Source, all those things are bringing down our stress and bringing down our level of inflammation,” she continued.
“If we’re under a lot of stress we’re going to have higher inflammation and higher inflammation actually can cause cellular damage to our bodies, particularly our brains,” Dr. Miller noted.
In addition to staying positive and participating in activities that help lower stress, remaining socially active and connected to other humans has also been associated with living a long life.
A study published in September 2019 found women who had strong social relationships had a 10% longer life spanTrusted Source and 41% better chance of living to age 85.
And research published in May 2023 showed that frequent participation in social activity was significantly associated with prolonged overall survivalTrusted Source in older adults.
“We are social beings with a social brain — we are wired to be part of a group with needs for both contributing value and being valued,” Dr. Sullivan explained.
“People who identify as lonelyTrusted Source have a […] greater risk of dying early than those who feel satisfied with their social life. The chronic stress of loneliness weakens our immune systems, making us more susceptible to infectious diseasesTrusted Source and chronic diseasesTrusted Source, especially cardiovascular disease and cancer.”
– Dr. Karen D. Sullivan
When actively socializing, Dr. Miller said, we are engaging in cognitive stimulation that helps keep the brain engaged and healthy.
“When we are involved with another person, there is that volley, that give and take,” she told MNT. “It’s like a tennis match — the ideas are going back and forth. And that type of cognitive stimulation actually inspires our brains to be more mentally agile, or like what we like to think of in neuropsychology as cognitive flexibilityTrusted Source.”
Plus, conversing and engaging with others helps you learn more information, think creatively, and stimulate problem-solving skills, resulting in what Dr. Miller referred to as a “whole-brain workout.”
“That type of engagement, that social stimulation, is what I would call nature’s brain bootcamp,” she added. “We’re literally engaging in bootcamp for our brain where we’re socializing, which is very different than if I was isolated and I didn’t have that opportunity.”
While experts agree a healthy diet, limiting stress, thinking positively, and staying socially active can potentially lead to a longer life, there are some other healthy habits that are also important.
For example, smoking can take years off your life. A study published in June 2020 found that not smoking and being socially engaged throughout older age were common in centenarians free from common chronic diseases.
Keeping a healthy weight is also important for longevity. Research published in 2017 concluded that a high body mass index (BMI) was associated with substantially shorterTrusted Source healthy and chronic disease-free life expectancy.
Regular exercise can also help you live longer. A study published in August 2022 found that light or moderate to vigorous physical activity were both associated with a lower risk of mortality in older women, while higher sedentary timeTrusted Source increased their mortality risk.
“Several studies have shown that physical activity is associated with lower risk of mortality in older adults,” Dr. Aladdin Shadyab, associate professor of epidemiology at the Herbert Wertheim School of Public Health & Human Longevity Science at UC San Diego, and senior author of the study told MNT.
“We were the first to show that higher levels of physical activity and lower time spent sedentary are associated with reduced risk of mortality, irrespective of having genes that predispose to a long life. These findings overall highlight the importance of maintaining a physically active lifestyle in old age to achieve longevity,” said Dr. Shadyab.
“I think maintaining a healthy diet and engaging in regular exercise is most important, particularly for older adults,” he added. “Even light activities, such as walking, are important for maintaining a long and healthy life in the aging population.”




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