Lead author, Jeffrey MD, and his colleagues recently published the study in the journal Depression & Anxiety.
" We know a lot about early risk factors, including psychological risk factors, temperament, behaviors and family relationships," said, professor in the Department of Psychiatry and Behavioral Neuroscience in UC's College of Medicine and a UC Health child and adolescent psychiatrist. "But we know incredibly little about the effects of environmental factors like air pollution and other environmental toxics on anxiety. "The study focused on a class of chemicals called PD Ethers that were used as flame retardants for products like furniture foam padding, wire insulation, rugs, upholstery, computers and appliances. Exposure to this during early brain development has been associated with cognitive deficits, reduced language skills and attention-deficit/hyperactivity disorder, and the chemicals were banned in the United States in 2004. Despite the ban, the professor said exposure to remains common, but its effect on anxiety symptoms had not been previously studied.
" One of the things that we know is that brain development starts relatively early, "he said. " We wanted to look at how different exposures at different points in a pregnancy impact brain development and how that potentially translates to a risk for anxiety or depression symptoms, which we know tend to manifest a bit later. The idea is to look at what is the earliest risk factor that we can really identify." The researchers used data from the Health Outcomes and Measures of the Environment (HOME) study, which was designed to measure the impact of fetal and early childhood exposures to environmental toxic ants like lead, mercury, pesticides, and more. The study enrolled 468 pregnant women in the Greater Cincinnati region from 2003-2006 and continued to follow up with their children up to 12 years later.
" We have this ongoing sample with lots of data about the moms and specifically about their environmental exposures in terms of blood that was obtained during their pregnancy," he said. "What we did is look at the relationship between exposure to those different environmental chemicals, specifically flame retardants, and that subsequent risk of developing anxiety or having anxiety symptoms." A total of 236 adolescents from the HOME study were given self-reporting anxiety and depression screenings around the age of 12. The study found that each time this levels doubled in a pregnant mother's blood sample was associated with increased anxiety scores in the adolescents, suggesting this exposure during pregnancy may be a risk factor for developing anxiety symptoms in early adolescence." When you look at a population level, and you see the effect of these ubiquitous chemicals increasing your baseline anxiety by 10% or 20%, that's really significant across the whole population," said the professor. "That increase in anxiety across a population means that many individuals may cross the line between having manageable anxiety and having an anxiety disorder." Moving forward, he said further research will aim to understand what brain regions are being affected by this exposure and if there are certain time periods in pregnancy that are more closely associated with the increased anxiety risk.
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