Abnormal functions of the ubiquitin - proteasome system (UPS)affects a number of cellular processes, including cell cycle regulation, cell growth, proliferation, apoptosis, DNA repair, and other cellular signalling processes. This is thought to be a key factor in the development of malignant tumours, cardiovascular diseases, neurodegenerative diseases and other diseases. As a result, the UPS has become one of the targets for the treatment of related diseases. Inhibiting the ubiquitin - proteasome system and regulating the degradation of related substrate proteins for disease treatment is an important drug - development strategy. The current research on small molecule inhibitors targeting the ubiquitin-proteasome system includes four main areas: ubiquitin-activating enzyme E1 inhibitors, ubiquitin-conjugating enzyme E2 inhibitors, ubiquitin ligase E3 inhibitors, and proteasome inhibitors.
KeyTec® Biotin-CBL-B, N-Avi
Species: Human; Expression Host: E.coli; Tag: N-terminal Avi; Sequence: A39-F426; Purity: SDS-PAGE
CAT. / P7HE0001S / P7HE0001L
KeyTec® c-Cbl, N-His-Avi
Species: Human; Expression Host: E.coli; Tag: N-terminal His-Avi; Sequence: G49-F434; Purity: SDS-PAGE
CAT. / P7HE0002S / P7HE0002L
KeyTec® COP1(WD40), N-His
Species: Human; Expression Host: Insect(Sf9); Tag: N-terminal His; Sequence: A386-V731; Purity: SDS-PAGE
CAT. / P7HI0003S / P7HI0003L
KeyTec® DDB1/CRBN, No tag/N-His
Species: Human; Expression Host: Insect(Sf9); Tag: No tag/N-terminal His; Sequence: M1-H1140(end)/M1-L442(end); Purity: SDS-PAGE; Application: TR-FRET; Activity: Binding activity
CAT. / P7HI0004S / P7HI0004L
KeyTec® IKZF1, N-GST; C-Avi
Species: Human; Expression Host: E.coli; Tag: N-terminal GST; C-terminal Avi; Sequence: H139-S168; Purity: SDS-PAGE
CAT. / P7HE0006S / P7HE0006L / P7HI0007S / P7HI0007L
KeyTec® IKZF2, N-GST; C-Avi
Species: Human; Expression Host: E.coli; Tag: N-terminal GST; C-terminal Avi; Sequence: H134-S163; Purity: SDS-PAGE
CAT. / P7HE0008S / P7HE0008L / P7HE0009S / P7HE0009L / P7HI0010S / P7HI0010L
KeyTec® IKZF3, N-GST; C-Avi
Species: Human; Expression Host: E.coli; Tag: N-terminal GST; C-terminal Avi; Sequence: H140-T169; Purity: SDS-PAGE
CAT. / P7HE0011S / P7HE0011L
KeyTec® UbcH5b, N-His
Species: Human; Expression Host: E.coli; Tag: N-terminal His; Sequence: M1-M147; Purity: SDS-PAGE
CAT. / P7HE0013S / P7HE0013L
KeyTec® UBE1(UBA1), N-Flag
Species: Human; Expression Host: Insect(Sf9); Tag: N-terminal Flag; Sequence: M1-R1058(end); Purity: SDS-PAGE
CAT. / P7HI0014S / P7HI0014L
KeyTec® UCH-L5(UCH37), N-His
Species: Human; Expression Host: E.coli; Tag: N-terminal His; Sequence: M1-329K(end); Purity: SDS-PAGE
CAT. / P7HE0015S / P7HE0015L
KeyTec® ULP-1, N-His
Species: Yeast; Expression Host: E.coli; Tag: N-terminal His; Sequence: K401-K621(end); Purity: SDS-PAGE
CAT. / P7YE0016S / P7YE0016L
KeyTec® USP13, N-GST
Species: Human; Expression Host: Insect(Sf9); Tag: N-terminal GST; Sequence: Y335-S863; Purity: SDS-PAGE
CAT. / P7HI0017S / P7HI0017L
KeyTec® USP25α, C-His
Species: Human; Expression Host: Insect(Sf9); Tag: C-terminal His; Sequence: M1-R1055(end); Purity: SDS-PAGE
CAT. / P7HI0018S / P7HI0018L
KeyTec® USP27, N-GST
Species: Human; Expression Host: E.coli; Tag: N-terminal GST; Sequence: M1-Y438(end); Purity: SDS-PAGE
CAT. / P7HE0019S / P7HE0019L
KeyTec® USP28, C-His
Species: Human; Expression Host: Insect(Sf9); Tag: C-terminal His; Sequence: M1-K1077(end); Purity: SDS-PAGE
CAT. / P7HI0020S / P7HI0020L
KeyTec® USP36, N-GST
Species: Human; Expression Host: E.coli; Tag: N-terminal GST; Sequence: A81-I461; Purity: SDS-PAGE
CAT. / P7HE0021S / P7HE0021L
OUTSTANDING FEATURES
Strict Quality Control
A strict QC (quality control) test report is provided for each batch.
Good Enzyme Activity
Each batch has been verified for enzyme activity.
Suitable for High-Throughput Screening
Verified by common homogeneous methods such as TR-FRET, Luminescence and fluorescence.
Cost-Effective
High-performance at competitive prices.
PRODUCT COMPETITIVENESS
For KeyTec® protein products, each batch of protein is subjected to a series of rigorous validation procedures to obtain data such as purity, monomer/polymer morphology, enzyme activity information, positive compound validation information, and so forth.
We provide ubiquitin elisa kit, in vitro ubiquitination kit, ubiquitin elisa, in vitro ubiquitination assay kit, ubiquitination assay kit, ubiquitination kit, in vivo ubiquitination assay, protease inhibition assay, preclinical research services, etc. For more information, please feel free to contact us!
You must be logged in to post a comment.