Top Heclin

Catalog No.GC40877

Heclin is an inhibitor of HECT E3 ubiquitin ligases (IC50s = 6.8, 6.3, and 6.9 μM for Smurf2, Nedd4, and WWP1 HECT ligase domains, respectively).

Products are for research use only. Not for human use. We do not sell to patients.

Product has been cited by 2 publications

Adv Sci (2024)：2400560.PMID:38874331Autophagy (2024).PMID:38566321

Description Chemical Properties Product Documents Related Products

Description

Heclin is an inhibitor of HECT E3 ubiquitin ligases (IC50s = 6.8, 6.3, and 6.9 μM for Smurf2, Nedd4, and WWP1 HECT ligase domains, respectively). Heclin inhibits autoubiquitination of Smurf2 in HEK293 cells expressing the human enzyme (IC50 = 9 μM) and reduces ubiquitination of Dishevelled 2 in HEK293 cells expressing Smurf2, Nedd4, or WWP2. Heclin is cytotoxic to HEK293 cells (IC50 = 45 μM).

Chemical Properties

Cas No.890605-54-6SDF

Canonical SMILESCC(C1=CC=C(NC(/C=C/C2=CC=C(CC)O2)=O)C=C1)=O

FormulaC17H17NO3M.Wt283.3

SolubilityDMSO: 20 mg/mL,Ethanol: 10 mg/mLStorageStore at -20°C

General tipsPlease select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.

To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.

Shipping ConditionEvaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.