The use of freeze-drying machine for medicine is more extensive, this kind of equipment is mainly used for serum, plasma, antibiotics, hormones, vaccines, various kinds of Chinese medicine (cordyceps sinensis, ginseng tablets, hopendrobium, black wolfberry), in the freeze dryer pharmaceutical industry process, to avoid the influence of heat, humidity, oxidation and other factors in the preparation of drugs, through freeze-drying technology to achieve effective drying of drugs. Protecting the active ingredients of drugs, improving the stability and long-term preservation ability of products, provides a reliable solution for drug production.
Benefits of Using Freeze Dryers in Pharmaceutics for Drug Preparations
Vacuum freeze-drying technology can greatly improve the storage and quality of medicine, and secondly, the stability of drugs has also been improved. Vacuum freezing technology can achieve uniform distribution of particles and improve the stability of drugs. Especially suitable for the following preparations:
(1) Products with unstable physical and chemical properties and poor heat resistance;
(2) Preparations requiring high fineness;
(3) Preparations requiring high filling accuracy;
(4) preparations that dissolve rapidly when used;
(5) Preparations of high economic value.
FAQs of Freeze Dryer in Pharmaceutics
The pharmaceutical freeze dryer makes products shrivel and bubble
Reasons: the sublimation stage heats up too fast or the sublimation stage has not yet ended before entering the analytical stage, resulting in high temperature, liquid evaporation into gas, resulting in volume reduction; Or dry products dissolve into the liquid, resulting in volume reduction, serious melting will cause bubbling phenomenon.
Solution: Reduce the temperature of sublimation stage, extend the time of sublimation stage and increase the vacuum degree of freeze-dried box, and control the product temperature below the eutectic point temperature of more than 5℃.
The Product Appears Atrophy, Cavity and Fragmentation Shortly After the Box
Cause: Incomplete drying and remaining ice crystals.
Solution: By extending the sublimation drying time or increasing the sublimation temperature to solve.
The product has no fixed shape after freeze-drying, and even the dried product is taken to the outside of the container by sublimation air
Reason: The concentration of solid matter in the product is too low to form a skeleton.
Solution: Increase the solid concentration.
Freeze dryers in the lyophilizer pharmaceutical industry produce products that are not full
Reason: The general solid substance concentration between 2% and 30% is appropriate, and the best concentration is 10% to 15%. The concentration of liquid medicine is too high, and the crystal structure formed during freezing is too dense, resulting in small pores and poor ventilation.
Solution: Reduce the concentration of the liquid or reduce the sublimation stage temperature appropriately.
Pharmaceutical freeze dryers produce products with hard shells on the surface
Reason: The surface of the product forms an airtight glass-like structure during pre-freezing, but the heat treatment is not done. After sublimation, the product heats up, some products melt and shrink, and the contraction of the product causes the surface layer to split, so the sublimation of the lower layer can proceed normally.
Solution: Do heat treatment when pre-freezing.
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