ATPγS tetralithium salt (Synonyms: ATPγS)
Catalog No.GC12574
ATPγS (tetralithium salt) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A.
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ATPγS tetralithium salt Chemical Structure
Cas No.: 93839-89-5
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5mg
$90.00
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10mg
$153.00
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25mg
$338.00
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Description
Adenosine 5'-(γ-thio)-triphosphate (lithium salt) is a stable analog of ATP that acts as a potent agonist of G protein-coupled P2Y2 and P2Y11 receptors (pEC50 = 5.52 for P2Y11).[1] Atpγs has been used to identify kinase substrates, has been implemented as a reagent in the synthesis of DNA N-acetylglucosamine analogs, and can serve as a substrate for the RNA-stimulated nucleotide hydrolysis and RNA unwinding activities of eukaryotic initiation factor-4A.[2],[3],[4]
Reference:
[1]. Jacobson, K.A., Ivanov, A.A., de Castro, S., et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 5(1), 75-89 (2009).
[2]. Knowles, J.R. Enzyme-catalyzed phosphoryl transfer reactions. Annual Reviews of Biochemistry 49, 877-919 (1980).
[3]. Chrysogelos, S., Register, J.C., III, and Griffith, J. The structure of recA protein-DNA filaments. 2 recA protein monomers unwind 17 base pairs of DNA by 11.5 degrees/base pair in the presence of adenosine 5'-O-(3-thiotriphosphate). The Journal of Biological Chemisty 258(20), 12624-12631 (1983).
[4]. Peck, M.L., and Herschlag, D. Adenosine 5'-O-(3-thio)triphosphate (ATPγS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor elF4A. RNA 9(10), 1180-1187 (2003).
Chemical Properties
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Cas No. |
93839-89-5 |
SDF |
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Synonyms |
ATPγS |
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Chemical Name |
P'-anhydride with phosphorothioic acid adenosine 5'-(trihydrogen diphosphate), tetralithium salt |
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Canonical SMILES |
S=P([O-])([O-])O[P@](O[P@](OC[C@H]1O[C@@H]([C@@H]([C@@H]1O)O)N2C3=NC=NC(N)=C3N=C2)([O-])=O)([O-])=O.[Li+].[Li+].[Li+].[Li+] |
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Formula |
C10H12Li4N5O12P3S |
M.Wt |
546.98 |
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Solubility |
10mg/mL in PBS, pH 7.2 |
Storage |
Store at -20°C |
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General tips |
Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. |
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Shipping Condition |
Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
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Complete Stock Solution Preparation Table
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Prepare stock solution |
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1 mg |
5 mg |
10 mg |
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1 mM |
1.8282 mL |
9.1411 mL |
18.2822 mL |
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5 mM |
365.6 μL |
1.8282 mL |
3.6564 mL |
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10 mM |
182.8 μL |
914.1 μL |
1.8282 mL |
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546.98
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