New Test For Breast Cancer Making Individualized Treatment Decisions A Reality
With a better understanding of the molecular basis of diseases such as breast cancer, the potential for personalized medicine, which is widely welcomed as the next frontier of medical advancement, is becoming a reality. Scientists are now able to develop treatments tailored to individual genetic profiles and tests to predict how patients will respond to existing treatments.
Today, some women with early-stage breast cancer and their doctors can use the Oncotype DX Breast Cancer Assay to make more informed treatment decisions. This service provides quantitative information about genes from women's tumors and produces a recurrence score from 0 to 100 that indicates whether the risk of cancer recurrence after treatment is high, moderate, or low.
ecotype DX is intended for patients with negative lymph node metastases and estrogen receptor-positive breast cancer who are expected to be treated with hormone therapy. About half of the 230,000 patients diagnosed with breast cancer each year in the United States fall into this category and are often treated with chemotherapy, a common treatment with serious side effects. According to clinical trials, chemotherapy improved patient survival in only 4 out of 100 patients, but this is due to limited information about whether thousands of women respond. We continue to choose costly and toxic treatments.
Recent studies have shown that women with a high recurrence score are more likely to benefit from chemotherapy, whereas women with a low recurrence score receive minimal benefits. Also, only 25% of women fall into the high-risk group compared to 50% in the low-risk group, suggesting that this combination therapy is not suitable for all patients.
Elizabeth Sloan in New York City is one of many breast cancer patients who are unlikely to respond to chemotherapy. Elizabeth, the active mother of two young boys, was thinking of having another child when she was diagnosed at the age of 40. She wanted to avoid chemotherapy with her annoying short-term side effects and potentially serious long-term consequences but wanted to make sure it didn't help her.
In collaboration with doctors Ruth Oratz, M.D. at the NYU Medical Center, Elizabeth chose the Oncotype DX test and she was pleased when her recurrence score turned out to be low. This indicates that she may not have benefited significantly from chemotherapy.
"Women with breast cancer are not the same. Oncotype DX provides information beyond standard measurements such as age, tumor size, and tumor grade to determine the likelihood of disease recurrence. "Dr. says. Its. "The Oncotype DX was given to Elizabeth and I gave her her confidence and peace of mind in choosing her most appropriate treatment."
For Susan Bakken of Denver, Colorado, the Oncotype DX is another type. Brought peace of mind. Susan's recurrence score showed that she was at high risk of cancer recurrence and was likely to benefit from chemotherapy.
"Based on other tests I did, my doctor said that he did not recommend chemotherapy in any other way. I was shocked when the results came out, but I was very happy because I believe this test saved my life, "Susan explained.
Elizabeth Sloan is also grateful for the information she received from her Oncotype DX. "Why to treat everyone the same with such toxic things when not all cancers are the same," she said. "It is very noteworthy that a doctor can ultimately distinguish one person's cancer from another. The
Oncotype DX is a simple test that only a doctor can prescribe. This is a standard breast mass. It is performed on a small amount of breast tumor tissue that is removed during excision, mastectomy, or biopsy, which means that no additional steps are required.
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