Liposomal Silybin
Name : Liposomal Silybin
Specification : 50%
Appearance : Light yellow powder
CAS. No. : 22888-70-6
Challenges with Conventional Silybin
Liposomal silymarin is primarily taken orally but has low solubility, low permeability and poor bioavailability. Approximately 20% to 50% of its active components are absorbed after oral administration, with about 80% secreted via bile and 10% entering the enterohepatic circulation, resulting in low oral bioavailability.
Liposomal Silybin Cas 22888-70-6
Liposomes are microvesicles composed of lipid bilayers, with a hydrophilic exterior and a lipophilic core. This unique structure allows them to encapsulate both water-soluble and lipid-soluble substances. Importantly, the bilayer structure of liposomes is similar to that of human cell membranes, enabling them to easily cross cell membranes. Formulating silybin and silymarin into liposomes can significantly enhance its bioavailability.
Numerous pharmacokinetic studies have shown that silybin liposomes improve bioavailability in both healthy individuals and patients with chronic liver disease. Research indicates that silybin liposomes achieve over 10 times higher bioavailability compared to conventional silymarin tablets. Several studies in animals and humans have demonstrated that silybin complexed with phosphatidylcholine exhibits superior bioavailability compared to non-complexed forms.
Efficacy of Liposomal Powder Silybin Cas 22888-70-6
Antioxidant: Silybin's antioxidant effects are linked to phenolic antioxidants within cells, preventing free radical formation, scavenging free radicals, and inhibiting lipid peroxidation of membranes (regulating membrane permeability).
Anti-inflammatory: Silybin's anti-inflammatory effects are associated with the structure of various cells and their pathways.
Anti-fibrotic: Silybin exerts anti-fibrotic effects on the liver directly or indirectly.
Hepatocyte Membrane Protection: Silybin protects hepatocytes through multiple mechanisms, including binding to hepatocyte membrane proteins, inhibiting lipid peroxidation to stabilize membrane permeability, supporting the liver's synthesis of protective substances, and preventing damage from harmful substances.
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