Recent findings that play a significant role in sperm development may shed light on the issue of infertility in men. Scientists at the Howard Hughes Medical Institute believe that they have discovered that genetic defects in Jhdma2a can lead to other conditions of infertility in men.
Howard Hughes' team noted that mice deficient in Jhdma2a genes were infertile and produced small amounts of abnormal sperm. One of the leading male reproductive health experts in the UK hopes the discovery could provide answers to why some men are unable to have children. It is not yet clear whether the majority of the reasons for men's "sub-fertility" are fully understood.
Abnormal sperm or very low sperm are two reasons why some men are unable to have children. Many studies look at genetic defects to be responsible for these conditions. Howard Hughes' team of experts believed that the Jhdma2a gene was essential for "spermiogenesis", which allowed DNA to be synthesized into a solid ball inside the sperm head needed to form an embryo. It may break the outer surface of the Egg. Supermogenesis is the final stage of sperm maturation, in which the cell forms its pseudopod, acquires the ability to crawl, and can fertilize the oocyte.
To determine if the Jhdma2a gene might affect sperm production, they studied mice and bred these animals without Jhdma2a genetics. These mice had unusually small testicles, had very low sperm production, and could not reproduce. He also noted that these mice not only had extraordinary testicles, but a small amount of the sperm they produced had unusual heads and tails that were found to be inactive. Sperm tests using a microscope dye revealed that the DNA in the sperm head was not properly packed.
Drs. Zhang, a project leader for the Howard Hughes team, said, "Genetic abnormalities may be the cause of some male infertility cases." "Because this gene has a great impact on the growth of active sperm, it has great potential as a target for new infertility treatments that may interfere with other functions in the body," he said. It means.
Although the genetic significance of Jhdma2a has already been demonstrated in mice, there is no guarantee that it will have the same effect on humans. The next big step for the group is to focus on the DNA of infertile men to see if it is not in them.
According to Drs. Alan PC, senior lecturer in urology at the University of Sheffield and secretary of the British Fertility Society, the genes that regulate sperm growth are not well understood. "The process of packing sperm DNA into sperm heads is different and we know very little about it. It would be very helpful to translate this study to men and see if it could explain why some men do not produce healthy sperm. So they are not fertile," he said.
Summary
A new discovery that plays a key role in sperm development could shed light on the issue of male infertility. Scientists at the Howard Hughes Medical Institute believe they have discovered that abnormalities in the Jhdma2a gene can lead to some cases of infertility in men. Howard Hughes' team noted [...]
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