Benzyl alcohol (Benzenemethanol) top 10

Benzyl alcohol (Benzenemethanol) is an aromatic alcohol widely used in medicine, cosmetics, food and industry. As a versatile solvent and preservative, benzenemethanol also exhibits mild anesthetic and antibacterial properties in various formulations.

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Description

Benzyl alcohol (Benzenemethanol) is an aromatic alcohol widely used in medicine, cosmetics, food and industry[1, 2]. Benzyl alcohol can be used as a local anesthetic for short-term superficial skin surgery[3]. Benzyl alcohol is naturally produced by many plants and is commonly found in fruits and teas, as well as in various essential oils[4].

In vivo, Benzyl alcohol (270mg/kg) was administered intraperitoneally to mice with acetaminophen (APAP)-induced liver injury, which significantly reduced plasma alanine aminotransferase (ALT) activity. Benzenemethanol can reduce the area of liver lobule necrosis, and alleviate APAP-induced liver injury[5]. Benzyl alcohol (270mg/kg) was administered intraperitoneally to mice with APAP-induced liver injury, which inhibited the release of cytokines, chemokines, and high-mobility group protein 1, and suppressed inflammasome signaling[6].

References:

[1] Scognamiglio J, Jones L, Vitale D, et al. Fragrance material review on benzyl alcohol[J]. Food and Chemical Toxicology, 2012, 50: S140-S160.

[2] Chan-Thaw C E, Savara A, Villa A. Selective benzyl alcohol oxidation over Pd catalysts[J]. Catalysts, 2018, 8(10): 431.

[3] Wilson L, Martin S. Benzyl alcohol as an alternative local anesthetic[J]. Annals of emergency medicine, 1999, 33(5): 495-499.

[4] Sell C. Chemistry of essential oils[M]//Handbook of essential oils. CRC Press, 2020: 161-189.

[5] Du K, McGill M R, Xie Y, et al. Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses[J]. Food and Chemical Toxicology, 2015, 86: 253-261.

[6] Cai C, Huang H, Whelan S, et al. Benzyl alcohol attenuates acetaminophen‐induced acute liver injury in a Toll‐like receptor‐4‐dependent pattern in mice[J]. Hepatology, 2014, 60(3): 990-1002.