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Leaky gut syndrome in conjunction with autism is still being researched; a number of studies and research are under way to better understand how the syndrome starts, why it can be prevalent in autistic children, and how to treat it. Simply, leaky guy syndrome is the inability of the intestinal wall to keep out large, unwanted molecules. This symptom of autism most often signifies that the intestinal wall has been altered to become permeable. Leaky gut syndrome in autistic children may occur because of increased sensitivity or allergies.